Loss-of-function screens are powerful tools for identifying gene contribution in a given biological context. Over the past decade, the RNA interference technology has become a dominant approach in the ...

Large genome-mapping consortia and thousands of genome-wide association studies have identified non-protein-coding elements in the genome as having a central role in various biological processes.

CRISPR-Cas9 based technologies have revolutionized many areas of biological research since the discovery that the bacterial immune system could be re-engineered for use in gene editing. One such area ...

Using a CRISPR screen, scientists at the Salk Institute have discovered a genetic “dial” to turn immune function up and down. The scientists suggest that the dial, which affects the development and ...