In this study we used a murine conditional knockout model to investigate the necessity of STAT5 for inducing FLT3-ITD-mediated disease. Furthermore, we intend to prove that the different phenotypes ...
Please provide your email address to receive an email when new articles are posted on . The STAT5 and STAT6 transcription factors activate Th9 cells. Th9 cells produce the IL-9 cytokine, which causes ...
JAK-STAT (Janus Kinase-Signal Transducer and Activator of Transcription) signaling is transiently activated by cytokines during hematopoiesis. Genetic lesions inducing constitutively activated ...
Expert Rev Endocrinol Metab. 2008;3(4):423-439. A better approach may be to identify the promoters to which STAT5A or -5B bind directly by performing chromatin immunoprecipitation (ChIP)-on-chip ...
Failure of Higher-Dose Paclitaxel to Improve Outcome in Patients With Metastatic Breast Cancer: Cancer and Leukemia Group B Trial 9342 Immunohistochemistry was used to detect active, ...
Researchers report that CAR T cells can stay active longer and mediate tumor killing more effectively when STAT5, a key signaling molecule, is kept in an active form within CAR T cells. Cancer ...
This study is led by Prof. Xin-Yuan Fu and Dr. Ke Jin from Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University. Tumor-infiltrating lymphocytes (TILs) play a key ...
Cancer immunotherapy using "designer" immune cells has revolutionized cancer treatment in recent years. In this type of therapy, T cells, a type of white blood cell, are collected from a patient's ...
Jens H Nielsen, University of Copenhagen, Department of Biomedical Research, Panum Institute, Bldg 6.5, Blegdamsvej 3C, DK-2200 Copenhagen N, Denmark Disclosure: The authors have no other relevant ...
Immunohistochemistry was used to detect active, tyrosine-phosphorylated Stat5 in paraffin-embedded breast cancer specimens from three archival tissue microarray materials A, B, and C. Material A ...
Cancer immunotherapy using "designer" immune cells has revolutionized cancer treatment in recent years. In this type of therapy, T cells, a type of white blood cell, are collected from a patient's ...
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