Cancer immunotherapy using "designer" immune cells has revolutionized cancer treatment in recent years. In this type of therapy, T cells, a type of white blood cell, are collected from a patient's ...
JAK-STAT (Janus Kinase-Signal Transducer and Activator of Transcription) signaling is transiently activated by cytokines during hematopoiesis. Genetic lesions inducing constitutively activated ...
Nuclear extracts from head and neck cancer cell lines were analysed by EMSA using the β-casein response element. Increased constitutive and TGF-α-stimulated Stat5 activation was detected in a series ...
Expert Rev Endocrinol Metab. 2008;3(4):423-439. A better approach may be to identify the promoters to which STAT5A or -5B bind directly by performing chromatin immunoprecipitation (ChIP)-on-chip ...
Immunotherapy uses a person’s own immune system to fight cancer. Immune checkpoint inhibitors are one class of immunotherapy that block specific proteins from slowing the immune response. As a result, ...
ANN ARBOR, Michigan — The protein STAT5 has long been an appealing target against cancer, but after decades of research it was consigned to the “undruggable” category. Now, University of Michigan ...
Researchers report that CAR T cells can stay active longer and mediate tumor killing more effectively when STAT5, a key signaling molecule, is kept in an active form within CAR T cells. Cancer ...
Researchers have uncovered a significant contributing factor to interferon resistance of malignant melanoma cells. The finding represents a step forward in understanding the molecular events that ...
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