Protein aggregation can occur due to a variety of causes. There are four classes that these causes can be categorized into, which are detailed below. Mutations that occur in the DNA sequence may or …

An understanding of protein aggregation in vitro is critical to the success of these efforts. The deliberate design of self‐assembling (aggregating) peptides and proteins to form bio‐inspired new materials is …

Jul 8, 2025 · Protein aggregation refers to the spontaneous association of proteins into larger, nonnative structures, leading to the formation of aggregates with distinct physicochemical properties compared …

Jul 31, 2025 · Protein aggregation occurs when unfolded or partially folded protein molecules interact with each other, forming clusters or larger complexes. This process can be triggered by various …

Jul 1, 2023 · Protein aggregation studies are important to understand the mechanism behind the occurrence of various protein misfolding and aggregation diseases. Protein aggregation can occur …

Are inclusion bodies the bane of your existence or a hidden opportunity? For researchers working with recombinant proteins in E. coli, finding your target protein in an insoluble pellet is a common …

Dec 17, 2025 · Protein aggregation is the process by which misfolded proteins adopt a conformation that cause its polymerization into aggregates and organized fibrils.

Nov 7, 2025 · Protein aggregation is a critical phenomenon that occurs when certain proteins, rather than folding into a single, unique native conformation, adopt alternative, often misfolded structures …

Protein aggregates represent an energetically stable, but non-functional alternative to the normal, functional, and soluble state of most proteins. In the context of human disease, aggregation occurs …

The aggregation process involves several protein-protein interactions, such as hydrophobic and electrostatic interactions, which are concentration-dependent; an increase in protein concentration …